![]() Disturbances in GABA levels are associated with many conditions involving the CNS, including anxiety, restlessness, and insomnia. GABA is an inhibitory neurotransmitter in the central nervous system (CNS). officinalis also modulates GABA by inhibiting GABA transaminase. The constituents, valerenic acid and valerenol, exhibit modulatory properties of gamma-aminobutyric acid (GABA) receptors. Some calming constituents in valerian are valerenic acid, valepotriates, borneol, lignans, and flavonoids. More recently, valerian has been studied for its supportive actions on the nervous system. The first recordings of valerian’s use for “nervous disorders” and insomnia were made in the Middle Ages. Its root has been used medicinally for centuries, dating back to at least the first century. Valerian ( Valeriana officinalis) is a botanical known best for its role in supporting sleep.
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